Targeting ER stress/ER stress response in myopathies
نویسندگان
چکیده
منابع مشابه
Heat shock response relieves ER stress.
Accumulation of misfolded protein in the endoplasmic reticulum (ER) causes stress. The unfolded protein response (UPR), a transcriptional induction pathway, is activated to relieve ER stress. Although UPR is not essential for viability, UPR-deficient cells are more sensitive to ER stress; ire1Delta cells cannot grow when challenged with tunicamycin or by overexpression of misfolded CPY(*). In t...
متن کاملChoosing the right response to ER stress
Cells use distinct unfolded protein response transducers to export different collagens during development.
متن کاملER stress and the unfolded protein response.
Conformational diseases are caused by mutations altering the folding pathway or final conformation of a protein. Many conformational diseases are caused by mutations in secretory proteins and reach from metabolic diseases, e.g. diabetes, to developmental and neurological diseases, e.g. Alzheimer's disease. Expression of mutant proteins disrupts protein folding in the endoplasmic reticulum (ER),...
متن کاملTargeting Chk1 in the replicative stress response
in response to DnA damage or interference with DnA synthesis, transformed cells characteristically activate various checkpoints, which together comprise an important component of a complex signaling network that has been termed the DnA damage response (DDR). Checkpoints identified so far are classified in two ways: (1) cell cycle checkpoints: the G1/s, intra-s or s, and G2/M checkpoint; or (2) ...
متن کاملER stress response, peroxisome proliferation, mitochondrial unfolded protein response and Golgi stress response.
The endoplasmic reticulum (ER) response has been thought a cytoprotective mechanism to cope with accumulation of unfolded proteins in the ER. Recent progress has made a quantum leap revealing that ER stress response can be regarded as an autoregulatory system adjusting the ER capacity to cellular demand. This Copernican change raised a novel fundamental question in cell biology: how do cells re...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2019
ISSN: 2213-2317
DOI: 10.1016/j.redox.2019.101232